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Article

Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumors

2 Jun 2021

Abstract excerpt

Molecular dynamics of developmental processes are repurposed by cancer cells to support cancer initiation and progression. Disruption of the delicate balance between cellular differentiation and plasticity during mammary development leads to breast cancer initiation and metastatic progression. STAT5A is essential for differentiation of secretory mammary alveolar epithelium. Active STAT5A characterizes breast...

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PMID: 34078871
DOI: 10.1038/s41389-021-00333-y

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