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Article

REST and Stress Resistance in the Aging Kidney.

Journal of the American Society of Nephrology : JASN - 1 Aug 2021

Magassa Sato, Aron Liviu, Hoguin Clément, Isnard Pierre, Terzi Fabiola, Legendre Christophe, Yankner Bruce A, Canaud Guillaume

Abstract excerpt

BACKGROUND: CKD is associated with the loss of functional nephr ons, leading to increased mechanical and metabolic stress in the remaining cells, particularly for cells constituting the filtration barrier, such as podocytes. The failure of podocytes to mount an adequate stress response can lead to further nephron loss and disease progression. However, the mechanisms that regulate this degenerative process in the...

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Source

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Identifiers

PMID: 34078664
DOI: 10.1681/ASN.2021020231
PMCID: PMC8455262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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