Article
Detecting Variants in the NBN Gene While Testing for Hereditary Breast Cancer: What to Do Next?
International journal of molecular sciences - 29 May 2021
Zuntini Roberta, Bonora Elena, Pradella Laura Maria, Amato Laura Benedetta, Vidone Michele, De Fanti Sara, Catucci Irene, Cortesi Laura, Medici Veronica, Ferrari Simona, Gasparre Giuseppe, Peterlongo Paolo, Sazzini Marco, Turchetti Daniela
Abstract excerpt
The NBN gene has been included in breast cancer (BC) multigene panels based on early studies suggesting an increased BC risk for carriers, though not confirmed by recent research. To evaluate the impact of NBN analysis, we assessed the results of NBN sequencing in 116 BRCA-negative BC patients and reviewed the literature. Three patients (2.6%) carried potentially relevant variants: two, apparently unrelated,...
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