Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2 French Canadian families with high risk of breast cancer.

BMC cancer - 12 Jun 2009

Desjardins Sylvie, Beauparlant Joly Charles, Labrie Yvan, Ouellette Geneviève, Durocher Francine

Abstract excerpt

BACKGROUND: The Nijmegen Breakage Syndrome is a chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency, and increased frequency of cancers. Familial studies on relatives of these patients indicated that they also appear to be at increased risk of cancer. METHODS: In a candidate gene study aiming at identifying genetic determinants of breast cancer susceptibility, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Canada

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to France

Share to Genes, BRCA1

Share to Genes, BRCA2

Share to Genes, Reporter

Share to Haploidy

Share to Luciferases

Source

Open in PubMed Open full text

Identifiers

PMID: 19523210
DOI: 10.1186/1471-2407-9-181
PMCID: PMC2702391

Genes

NBN
BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2 French Canadian families with high risk of breast cancer.PMID 19523210Read ↗

Determination of the frequency of the common 657Del5 Nnijmegen breakage syndrome mutation in the German population: No association with risk of breast cancerSemantic proximity Read ↗

New mutations and protein variants of NBS1 are identified in cancer cell lines.Semantic proximity Read ↗

Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line.Semantic proximity Read ↗

Current evidence on the relationship between two polymorphisms in the NBS1 gene and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

Functional variants in NBS1 and cancer risk: evidence from a meta-analysis of 60 publications with 111 individual studies.Semantic proximity Read ↗

Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group.Semantic proximity Read ↗

NTHL1 is a recessive cancer susceptibility gene.Semantic proximity Read ↗

Identification of a rare germline NBN gene mutation by whole exome sequencing in a lung-cancer survivor from a large family with various types of cancer.Semantic proximity Read ↗

NBN Pathogenic Germline Variants are Associated with Pan-Cancer Susceptibility and In Vitro DNA Damage Response Defects.Semantic proximity Read ↗

Nijmegen Breakage Syndrome mutations and risk of breast cancer.Semantic proximity Read ↗

Heterozygous germ-line mutations in the NBN gene predispose to medulloblastoma in pediatric patients.Semantic proximity Read ↗

657del5 mutation in the gene for Nijmegen breakage syndrome (NBS1) in a cohort of Russian children with lymphoid tissue malignancies and controls.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.