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Article

Statistical Learning Methods Applicable to Genome-Wide Association Studies on Unbalanced Case-Control Disease Data.

Genes - 13 May 2021

Dai Xiaotian, Fu Guifang, Zhao Shaofei, Zeng Yifei

Abstract excerpt

Despite the fact that imbalance between case and control groups is prevalent in genome-wide association studies (GWAS), it is often overlooked. This imbalance is getting more significant and urgent as the rapid growth of biobanks and electronic health records have enabled the collection of thousands of phenotypes from large cohorts, in particular for diseases with low prevalence. The unbalanced binary traits pose...

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PMID: 34068248
DOI: 10.3390/genes12050736
PMCID: PMC8153154

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