Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1-4 in Italy.

doi:10.1038/s41598-018-26862-y

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Article

Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1-4 in Italy.

Scientific reports - 12 Jun 2018

Bertoli Ada, Sorbo Maria Chiara, Aragri Marianna, Lenci Ilaria, Teti Elisabetta, Polilli Ennio, Di Maio Velia Chiara, Gianserra Laura, Biliotti Elisa, Masetti Chiara, Magni Carlo F, Babudieri Sergio, Nicolini Laura A, Milana Martina, Cacciatore Pierluigi, Sarmati Loredana, Pellicelli Adriano, Paolucci Stefania, Craxì Antonio, Morisco Filomena, Palitti Valeria Pace, Siciliano Massimo, Coppola Nicola, Iapadre Nerio, Puoti Massimo, Rizzardini Giuliano, Taliani Gloria, Pasquazzi Caterina, Andreoni Massimo, Parruti Giustino, Angelico Mario, Perno Carlo Federico, Cento Valeria, Ceccherini-Silberstein Francesca

Abstract excerpt

Natural resistance-associated substitutions (RASs) are reported with highly variable prevalence across different HCV genotypes (GTs). Frequency of natural RASs in a large Italian real-life cohort of patients infected with the 4 main HCV-GTs was investigated. NS3, NS5A and NS5B sequences were analysed in 1445 HCV-infected DAA-naïve patients. Sanger-sequencing was performed by home-made protocols on 464 GT1a, 585...

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PMID: 29895871
DOI: 10.1038/s41598-018-26862-y
PMCID: PMC5997636

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