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Article

KLOTHO gene polymorphism of G395A is associated with kidney stones.

American journal of nephrology - 1 Jan 2011

Telci Dilek, Dogan Ali Umman, Ozbek Emin, Polat Emre Can, Simsek Abdulmuttalip, Cakir Suleyman Sami, Yeloglu Hakki Okan, Sahin Fikrettin

Abstract excerpt

BACKGROUND/AIMS: KLOTHO, a type-1 transmembrane protein with glucurodinase activity, is expressed in tissues responsible for calcium homeostasis such as the kidney, parathyroid gland and the epithelium of the choroid plexus in the brain. Given the emerging evidence indicating a novel regulatory function for KLOTHO protein in renal calcium and phosphate homeostasis, the present study aims to investigate the...

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Identifiers

PMID: 21422754
DOI: 10.1159/000325505

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