Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis.

doi:10.1128/mBio.00369-21

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Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis.

mBio - 29 Jun 2021

Gonçalves Samuel M, Antunes Daniela, Leite Luis, Mercier Toine, Horst Rob Ter, Vieira Joana, Espada Eduardo, Pinho Vaz Carlos, Branca Rosa, Campilho Fernando, Freitas Fátima, Ligeiro Dário, Marques António, van de Veerdonk Frank L, Joosten Leo A B, Lagrou Katrien, Maertens Johan, Netea Mihai G, Lacerda João F, Campos António, Cunha Cristina, Carvalho Agostinho

Abstract excerpt

Activation of immune cells in response to fungal infection involves the reprogramming of their cellular metabolism to support antimicrobial effector functions. Although metabolic pathways such as glycolysis are known to represent critical regulatory nodes in antifungal immunity, it remains undetermined whether these are differentially regulated at the interindividual level. In this study, we identify a key role...

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PMID: 34044589
DOI: 10.1128/mBio.00369-21
PMCID: PMC8263003

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