Article
An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility.
PloS one - 1 Jan 2017
Matzaraki Vasiliki, Gresnigt Mark S, Jaeger Martin, Ricaño-Ponce Isis, Johnson Melissa D, Oosting Marije, Franke Lude, Withoff Sebo, Perfect John R, Joosten Leo A B, Kullberg Bart Jan, van de Veerdonk Frank L, Jonkers Iris, Li Yang, Wijmenga Cisca, Netea Mihai G, Kumar Vinod
Abstract excerpt
Candidaemia is a bloodstream infection caused by Candida species that primarily affects specific groups of at-risk patients. Because only small candidaemia patient cohorts are available, classical genome wide association cannot be used to identify Candida susceptibility genes. Therefore, we have applied an integrative genomics approach to identify novel susceptibility genes and pathways for candidaemia....
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