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Article

Inborn errors of IL-6 family cytokine responses.

Current opinion in immunology - 1 Oct 2021

Chen Yin-Huai, Spencer Sarah, Laurence Arian, Thaventhiran James Ed, Uhlig Holm H

Abstract excerpt

The IL-6 family of cytokines mediates functions in host protective immunity, development of multiple organs, tissue regeneration and metabolism. Inborn errors in cytokines or cytokine receptor units highlight specific roles for IL-6, IL-11, LIF, OSM, and CLC signaling whereas incomplete loss-of-function variants in the common receptor chain GP130 encoded by IL6ST or the transcription factor STAT3, as well as...

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Identifiers

PMID: 34044328
DOI: 10.1016/j.coi.2021.04.007
PMCID: PMC8591178

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