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Article

Spliceosome-regulated RSRP1-dependent NF-κB activation promotes the glioblastoma mesenchymal phenotype.

Neuro-oncology - 1 Oct 2021

Li Yaomin, Wang Xiran, Qi Songtao, Gao Lei, Huang Guanglong, Ren Zhonglu, Li Kaishu, Peng Yuping, Yi Guozhong, Guo Jinglin, Yang Runwei, Wang Hai, Zhang Xian, Liu Yawei

Abstract excerpt

BACKGROUND: The glioblastoma (GBM) mesenchymal (MES) phenotype, induced by NF-κB activation, is characterized by aggressive tumor progression and poor clinical outcomes. Our previous analysis indicated that MES GBM has a unique alternative splicing (AS) pattern; however, the underlying mechanism remains obscure. We aimed to reveal how splicing regulation contributes to MES phenotype promotion in GBM. METHODS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34042961
DOI: 10.1093/neuonc/noab126
PMCID: PMC8485435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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