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Article

Deep learning for large scale MRI-based morphological phenotyping of osteoarthritis.

Scientific reports - 25 May 2021

Namiri Nikan K, Lee Jinhee, Astuto Bruno, Liu Felix, Shah Rutwik, Majumdar Sharmila, Pedoia Valentina

Abstract excerpt

Osteoarthritis (OA) develops through heterogenous pathophysiologic pathways. As a result, no regulatory agency approved disease modifying OA drugs are available to date. Stratifying knees into MRI-based morphological phenotypes may provide insight into predicting future OA incidence, leading to improved inclusion criteria and efficacy of therapeutics. We trained convolutional neural networks to classify bone,...

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Identifiers

PMID: 34035386
DOI: 10.1038/s41598-021-90292-6
PMCID: PMC8149826

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