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Article

Long-read sequencing reveals extensive gut phageome structural variations driven by genetic exchange with bacterial hosts.

Science advances - 16 Aug 2024

Lai Senying, Wang Huarui, Bork Peer, Chen Wei-Hua, Zhao Xing-Ming

Abstract excerpt

Genetic variations are instrumental for unraveling phage evolution and deciphering their functional implications. Here, we explore the underlying fine-scale genetic variations in the gut phageome, especially structural variations (SVs). By using virome-enriched long-read metagenomic sequencing across 91 individuals, we identified a total of 14,438 nonredundant phage SVs and revealed their prevalence within the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39141729
DOI: 10.1126/sciadv.adn3316
PMCID: PMC11323893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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