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Article

Altered regulation of cell migration in IRF6-mutated orofacial cleft patients-derived primary cells reveals a novel role of Rho GTPases in cleft/lip palate development.

Cells & development - 1 Jun 2021

Ghassibe-Sabbagh Michella, El Hajj Joelle, Al Saneh Mounir, El Baba Nada, Abou Issa Jamil, Al Haddad Maria, El Atat Oula, Sabbagh Joseph, Abou Chebel Naji, El-Sibai Mirvat

Abstract excerpt

Orofacial clefts are the most common congenital craniofacial birth defects. They occur from a failure in cell proliferation and fusion of neural crest cells of the lip buds and/or palatal shelves. In this study, we investigate the genetic basis and molecular mechanisms in primary cells derived from a cleft and lip palate patient presenting van der Woude syndrome (VWS). Since mutations in the integrin genes are...

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Identifiers

PMID: 33994351
DOI: 10.1016/j.cdev.2021.203674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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