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Article

Effects of small interfering RNA-mediated silencing of susceptibility genes of non-syndromic cleft lip with or without cleft palate on cell proliferation and migration.

International journal of pediatric otorhinolaryngology - 1 Nov 2020

Li Meng-Xue, Li Zheng, Zhang Rui, Yu Yue, Wang Lu-Shan, Wang Qi, Ding Zhen, Zhang Jin-Peng, Zhang Mei-Rong, Xu Li-Chun

Abstract excerpt

BACKGROUND: Non-syndrome cleft lip with or without cleft palate (NSCL/P) is the most common congenital defect with a complex etiology involving both genetic and environmental factors. Our previous research has identified susceptibility genes of NSCL/P using whole-exome sequencing. The study was to determine the effects of small interfering RNA (siRNA)-mediated silencing of genes on cell proliferation and...

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PMID: 33152973
DOI: 10.1016/j.ijporl.2020.110382

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