Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson's disease.

Scientific reports - 21 May 2021

Maszlag-Török Rita, Boros Fanni A, Vécsei László, Klivényi Péter

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disease caused by complex interaction between genetic and environmental factors. There is a growing body of evidence of the involvement of sirtuins (SIRTs) in disease pathomechanism. SIRTs are NAD+-dependent histone deacetylases which take part in various cellular functions. However, available data of the relationship between SIRT gene polymorphisms and PD is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alleles
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Haplotypes

Share to Parkinson Disease

Share to Sirtuin 1

Share to Sirtuins

Source

Open in PubMed Open full text

Identifiers

PMID: 34021216
DOI: 10.1038/s41598-021-90059-z
PMCID: PMC8140123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson's disease.PMID 34021216Read ↗

Genetic association of sirtuin genes and Parkinson's disease.Semantic proximity Read ↗

Sirtuins as modifiers of Parkinson's disease pathologySemantic proximity Read ↗

Emerging Role of Sirtuin 2 in Parkinson’s DiseaseSemantic proximity Read ↗

Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery PerspectiveSemantic proximity Read ↗

Mitochondrial Sirtuins in Parkinson’s DiseaseSemantic proximity Read ↗

miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson’s DiseaseSemantic proximity Read ↗

SIRT1 and SIRT2 Activity Control in Neurodegenerative DiseasesSemantic proximity Read ↗

Genetic analysis of SIRT1 gene promoter in sporadic Parkinson’s diseaseSemantic proximity Read ↗

Sirtuin family in autoimmune diseasesSemantic proximity Read ↗

Sirtuin dysregulation in Parkinson's disease: Implications of acetylation and deacetylation processesSemantic proximity Read ↗

The Role of Sirtuin 1 (SIRT1) in NeurodegenerationSemantic proximity Read ↗

Elevated Serum SIRT 2 May Differentiate Parkinson’s Disease From Atypical Parkinsonian SyndromesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.