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The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

21 May 2021

Abstract excerpt

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic and has claimed over 2 million lives worldwide. Although the genetic sequences of SARS-CoV and SARS-CoV-2 have high homology, the clinical and pathological characteristics of COVID-19 differ significantly from those of SARS. How and whether SARS-CoV-2 evades (cellular) immune surveillance requires...

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PMID: 34021074
DOI: 10.1073/pnas.2024202118

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