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Article

Multiple Immunoglobulin κ Gene Rearrangements within a Single Clone Unraveled by Next-Generation Sequencing-Based Clonality Assessment.

The Journal of molecular diagnostics : JMD - 1 Sept 2021

Leenders A Meilinde, Kroeze Leonie I, Rijntjes Jos, Luijks Jeroen, Hebeda Konnie M, Darzentas Nikos, Langerak Anton W, van den Brand Michiel, Groenen Patricia J T A

Abstract excerpt

Clonality assessment of the Ig heavy- and light-chain genes (IGH and IGK) using GeneScan analysis is an important supplemental assay in diagnostic testing for lymphoma. Occasionally cases with an IGK rearrangement pattern that cannot readily be assigned to a monoclonal lymphoma are encountered, whereas the occurrence of biclonal lymphomas is rare, and the result of the IGH locus of these cases is in line with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34020040
DOI: 10.1016/j.jmoldx.2021.05.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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