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Attenuated dengue viruses are genetically more diverse than their respective wild-type parents

20 May 2021

Abstract excerpt

Dengue poses a significant burden of individual health, health systems and the economy in dengue endemic regions. As such, dengue vaccine development has been an active area of research. Previous studies selected attenuated vaccine candidates based on plaque size. However, these candidates led to mixed safety outcome in clinical trials, suggesting it is insufficiently informative as an indicator of dengue virus...

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PMID: 34017007
DOI: 10.1038/s41541-021-00340-5

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