Article
Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents.
Scientific reports - 18 May 2021
Kwok Andy T, Mohamed Nequesha S, Plate Johannes F, Yammani Raghunatha R, Rosas Samuel, Bateman Ted A, Livingston Eric, Moore Joseph E, Kerr Bethany A, Lee Jingyun, Furdui Cristina M, Tan Li, Bouxsein Mary L, Ferguson Virginia L, Stodieck Louis S, Zawieja David C, Delp Michael D, Mao Xiao W, Willey Jeffrey S
Abstract excerpt
Reduced knee weight-bearing from prescription or sedentary lifestyles are associated with cartilage degradation; effects on the meniscus are unclear. Rodents exposed to spaceflight or hind limb unloading (HLU) represent unique opportunities to evaluate this question. This study evaluated arthritic changes in the medial knee compartment that bears the highest loads across the knee after actual and simulated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.