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Mutational landscape of DNAH1 in Chinese patients with multiple morphological abnormalities of the sperm flagella: cohort study and literature review.

Journal of assisted reproduction and genetics - 1 Aug 2021

Yu Wen, An Miao, Xu Yang, Gao Qingqiang, Lu Mujun, Li Yingying, Zhang Li, Wang Hongxiang, Xu Zhipeng

Abstract excerpt

PURPOSE: Multiple morphological abnormalities of the sperm flagella (MMAF) are important causes of male infertility. Mutations in DNAH1 are the main causative factors proven so far. We aim to determine the mutational landscape of DNAH1 in Chinese patients with MMAF. METHODS: Forty-one Chinese patients with MMAF were enrolled and underwent a 10-gene next-generation sequencing panel screening. RESULTS: Only the...

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Abnormalities, Multiple
Asian People
Cohort Studies
Dyneins
Infertility, Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33929677
DOI: 10.1007/s10815-021-02201-5
PMCID: PMC8417202

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