Secreted frizzled‐related protein 1 (<i>SFRP1</i>) is highly upregulated in keratoconus epithelium: a novel finding highlighting a new potential focus for keratoconus research and treatment

Abstract excerpt

PURPOSE: To investigate the expression of Wnt signalling pathway genes in keratoconic (KC) epithelium. METHODS: RNA was extracted from the epithelium of four KC patients undergoing corneal transplantation and five age-matched controls. The expression of 84 genes known to be involved in the Wnt signalling pathway was tested by reverse transcription-polymerase chain reaction (RT-PCR) with a pathway-targeted array...

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