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Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes

1 Apr 2021

Abstract excerpt

Objective To discover genetic determinants of Parkinson disease (PD) motor subtypes, including tremor dominant (TD) and postural instability/gait difficulty (PIGD) forms. Methods In 3,212 PD cases of European ancestry, we performed a genome-wide association study (GWAS) examining 2 complementary outcome traits derived from the Unified Parkinson9s Disease Rating Scale, including dichotomous motor subtype (TD vs...

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PMID: 33987465
DOI: 10.1212/nxg.0000000000000557

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