Polymorphism of the DNA repair gene XDP increases the risk of systemic lupus erythematosus but not multiple sclerosis in the Iranian population.

doi:10.1016/j.msard.2021.102985

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Article

Polymorphism of the DNA repair gene XDP increases the risk of systemic lupus erythematosus but not multiple sclerosis in the Iranian population.

Multiple sclerosis and related disorders - 1 Jul 2021

Saravani Mohsen, Nematollahi Mohammad Hadi, Shahroudi Mahdieh Jafari, Heidary Zohreh, Sandoughi Mahnaz, Maruei-Milan Rostam, Mehrabani Mehrnaz

Abstract excerpt

BACKGROUND: Xeroderma pigmentosum group D ( XPD ) is an essential component of the nucleotide excision repair (NER) pathway, which can play a major role in DNA repair processes. A deficiency in this pathway was suggested as a causative factor of autoimmune diseases. Therefore, the current study aimed to investigate the relationship between XPD Lys751Gln polymorphism (rs13181) as one of the most common XDP...

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PMID: 33984652
DOI: 10.1016/j.msard.2021.102985

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