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Machine learning workflows identify a microRNA signature of insulin transcription in human tissues

1 Apr 2021

Abstract excerpt

Dicer knockout mouse models demonstrated a key role for microRNAs in pancreatic β-cell function. Studies to identify specific microRNA(s) associated with human (pro-)endocrine gene expression are needed. We profiled microRNAs and key pancreatic genes in 353 human tissue samples. Machine learning workflows identified microRNAs associated with (pro-)insulin transcripts in a discovery set of islets (n = 30) and...

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PMID: 33981968
DOI: 10.1016/j.isci.2021.102379

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