Article
miR-204 is associated with an endocrine phenotype in human pancreatic islets but does not regulate the insulin mRNA through MAFA.
Scientific reports - 25 Oct 2017
Marzinotto Ilaria, Pellegrini Silvia, Brigatti Cristina, Nano Rita, Melzi Raffaella, Mercalli Alessia, Liberati Daniela, Sordi Valeria, Ferrari Maurizio, Falconi Massimo, Doglioni Claudio, Ravassard Philippe, Piemonti Lorenzo, Lampasona Vito
Abstract excerpt
miR-204 has been proposed to modulate insulin expression in human pancreatic islets by regulating the expression of the MAFA transcript, and in turn insulin transcription. We investigated miR-204 expression in pancreatic endocrine tumors (PET), a panel of human tissues, tissues derived from pancreatic islet purification, and in induced pluripotent stem cells (iPSCs) differentiated towards a pancreatic endocrine...
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