Article
Transferrable protection by gut microbes against STING-associated lung disease.
Cell reports - 11 May 2021
Platt Derek J, Lawrence Dylan, Rodgers Rachel, Schriefer Lawrence, Qian Wei, Miner Cathrine A, Menos Amber M, Kennedy Elizabeth A, Peterson Stefan T, Stinson W Alexander, Baldridge Megan T, Miner Jonathan J
Abstract excerpt
STING modulates immunity by responding to bacterial and endogenous cyclic dinucleotides (CDNs). Humans and mice with STING gain-of-function mutations develop a syndrome known as STING-associated vasculopathy with onset in infancy (SAVI), which is characterized by inflammatory or fibrosing lung disease. We hypothesized that hyperresponsiveness of gain-of-function STING to bacterial CDNs might explain...
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