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Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants.

Communications biology - 15 Feb 2021

Wang Rui, Chen Jiahui, Gao Kaifu, Hozumi Yuta, Yin Changchuan, Wei Guo-Wei

Abstract excerpt

SARS-CoV-2 has been mutating since it was first sequenced in early January 2020. Here, we analyze 45,494 complete SARS-CoV-2 geneome sequences in the world to understand their mutations. Among them, 12,754 sequences are from the United States. Our analysis suggests the presence of four substrains and eleven top mutations in the United States. These eleven top mutations belong to 3 disconnected groups. The first...

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Identifiers

PMID: 33589648
DOI: 10.1038/s42003-021-01754-6
PMCID: PMC7884689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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