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Article

Partial ORF1ab Gene Target Failure with Omicron BA.2.12.1.

Journal of clinical microbiology - 15 Jun 2022

Rodino Kyle G, Peaper David R, Kelly Brendan J, Bushman Frederic, Marques Andrew, Adhikari Hriju, Tu Zheng Jin, Marrero Rolon Rebecca, Westblade Lars F, Green Daniel A, Berry Gregory J, Wu Fann, Annavajhala Medini K, Uhlemann Anne-Catrin, Parikh Bijal A, McMillen Tracy, Jani Krupa, Babady N Esther, Hahn Anne M, Koch Robert T, Grubaugh Nathan D, Rhoads Daniel D

Abstract excerpt

Mutations in the genome of SARS-CoV-2 can affect the performance of molecular diagnostic assays. In some cases, such as S-gene target failure, the impact can serve as a unique indicator of a particular SARS-CoV-2 variant and provide a method for rapid detection. Here, we describe partial ORF1ab gene target failure (pOGTF) on the cobas SARS-CoV-2 assays, defined by a ≥2-thermocycle delay in detection of the ORF1ab...

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Identifiers

PMID: 35582905
DOI: 10.1128/jcm.00600-22
PMCID: PMC9199403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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