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Article

Interpretable Fine-Grained Phenotypes of Subcellular Dynamics via Unsupervised Deep Learning.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Nov 2024

Wang Chuangqi, Choi Hee June, Woodbury Lucy, Lee Kwonmoo

Abstract excerpt

Uncovering fine-grained phenotypes of live cell dynamics is pivotal for a comprehensive understanding of the heterogeneity in healthy and diseased biological processes. However, this endeavor poses significant technical challenges for unsupervised machine learning, requiring the extraction of features that not only faithfully preserve this heterogeneity but also effectively discriminate between established...

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PMID: 39239705
DOI: 10.1002/advs.202403547
PMCID: PMC11538677

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