Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Understanding and interpretation of a variant of uncertain significance (VUS) genetic test result by pediatric providers who do not specialize in genetics.

Journal of genetic counseling - 1 Dec 2021

Menke Chelsea, Nagaraj Chinmayee B, Dawson Brian, He Hua, Tawde Sanjukta, Wakefield Emily G

Abstract excerpt

The advancement of genetic testing technologies has allowed for better diagnosis and management of patients, but also results in more variants of uncertain significance (VUSs) due to the increased number of genes being analyzed. There are more genetic tests available and more providers who do not specialize in genetics ordering genetic testing, but few studies examining how providers who do not specialize in...

Topics

Child
Genetic Predisposition to Disease
Genetic Testing
Humans
Knowledge

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33969574
DOI: 10.1002/jgc4.1422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Understanding and interpretation of a variant of uncertain significance (VUS) genetic test result by pediatric providers who do not specialize in genetics.PMID 33969574Read ↗

Physician interpretation of variants of uncertain significance.Semantic proximity Read ↗

Pitfalls and challenges in genetic test interpretation: An exploration of genetic professionals experience with interpretation of resultsSemantic proximity Read ↗

The Challenge of Genetic Variants of Uncertain Clinical Significance : A Narrative Review.Semantic proximity Read ↗

Evaluation of Clinical Practices Related to Variants of Uncertain Significance Results in Inherited Cardiac Arrhythmia and Inherited Cardiomyopathy Genes.Semantic proximity Read ↗

Physicians' perspectives on the uncertainties and implications of chromosomal microarray testing of children and familiesSemantic proximity Read ↗

Genetic counselors' practices and confidence regarding variant of uncertain significance results and reclassification from BRCA testing.Semantic proximity Read ↗

A preliminary investigation of genetic counselors' information needs when receiving a variant of uncertain significance result: a mixed methods study.Semantic proximity Read ↗

Clinical and laboratory genetic counselor attitudes on the reporting of variants of uncertain significance for multigene cancer panels.Semantic proximity Read ↗

Assessing patient communication preferences for reclassified variants of uncertain significance in a general genetics clinic.Semantic proximity Read ↗

Variants of unknown significance in BRCA testing: impact on risk perception, worry, prevention and counseling.Semantic proximity Read ↗

Genomic uncertainty and genetic counsellors' professional authority.Semantic proximity Read ↗

The Development and Evaluation of Novel Patient Educational Material for a Variant of Uncertain Significance (VUS) Result in Hereditary Cancer Genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.