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Article

Assessing patient communication preferences for reclassified variants of uncertain significance in a general genetics clinic.

Journal of genetic counseling - 1 Feb 2026

Brush Eden R, Naik Ketki, Close Charlotte, Nesheiwat Nora, Berger Sara M, Dews Alyssa, Ahimaz Priyanka

Abstract excerpt

Increased detection of variants of uncertain significance (VUS) from clinical genomic testing has brought about more frequent variant reclassifications which have the potential to impact patient care and well-being. However, the lack of best practice guidelines on communicating reclassified results to patients and limited genetic counselor (GC) bandwidth has led to inconsistent disclosure practices and potential...

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PMID: 41611530
DOI: 10.1002/jgc4.70173

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GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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