Article
Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.
Developmental cell - 17 May 2021
Chen Tingfang, Rohacek Alex M, Caporizzo Matthew, Nankali Amir, Smits Jeroen J, Oostrik Jaap, Lanting Cornelis P, Kücük Erdi, Gilissen Christian, van de Kamp Jiddeke M, Pennings Ronald J E, Rakowiecki Staci M, Kaestner Klaus H, Ohlemiller Kevin K, Oghalai John S, Kremer Hannie, Prosser Benjamin L, Epstein Douglas J
Abstract excerpt
In mammals, sound is detected by mechanosensory hair cells that are activated in response to vibrations at frequency-dependent positions along the cochlear duct. We demonstrate that inner ear supporting cells provide a structural framework for transmitting sound energy through the cochlear partition. Humans and mice with mutations in GAS2, encoding a cytoskeletal regulatory protein, exhibit hearing loss due to...
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