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Article

Graft-versus-host disease after liver transplantation is associated with bone marrow failure, hemophagocytosis, and DNMT3A mutations.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Dec 2021

Newell Laura F, Dunlap Jennifer, Gatter Ken, Bagby Grover C, Press Richard D, Cook Rachel J, Fletcher Luke, Leonard Jessica T, Leong Kelli M, Bubalo Joseph S, Olyaei Ali, Deloughery Thomas G, Maziarz Richard T, Maynard Erin, Orloff Susan L, Enestvedt C Kristian

Abstract excerpt

Graft-versus-host disease after liver transplantation (LT-GVHD) is rare, frequently fatal, and associated with bone marrow failure (BMF), cytopenias, and hyperferritinemia. Given hyperferritinemia and cytopenias are present in hemophagocytic lymphohistiocytosis (HLH), and somatic mutations in hematopoietic cells are associated with hyperinflammatory responses (clonal hematopoiesis of indeterminate potential,...

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Identifiers

PMID: 33961341
DOI: 10.1111/ajt.16635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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