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Reduced-intensity conditioning for hematopoietic cell transplant for HLH and primary immune deficiencies

11 Jul 2018

Abstract excerpt

Allogeneic hematopoietic cell transplantation (HCT) with myeloablative conditioning for disorders associated with excessive inflammation such as hemophagocytic lymphohistiocytosis (HLH) is associated with early mortality. A multicenter prospective phase 2 trial of reduced-intensity conditioning with melphalan, fludarabine, and intermediate-timing alemtuzumab was conducted for HLA matched or single HLA locus...

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PMID: 29997222
DOI: 10.1182/blood-2018-01-828277

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