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Article

Rapid diagnosis of FHL3 by flow cytometric detection of intraplatelet Munc13-4 protein

9 Jun 2011

Abstract excerpt

Familial hemophagocytic lymphohistiocytosis (FHL) is a potentially lethal genetic disorder of immune dysregulation that requires prompt and accurate diagnosis to initiate life-saving immunosuppressive therapy and to prepare for hematopoietic stem cell transplantation. In the present study, 85 patients with hemophagocytic lymphohistiocytosis were screened for FHL3 by Western blotting using platelets and by natural...

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PMID: 21653941
DOI: 10.1182/blood-2011-01-329540

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