Article
Systematic interrogation of mutation groupings reveals divergent downstream expression programs within key cancer genes.
BMC bioinformatics - 6 May 2021
Grzadkowski Michal R, Holly Hannah D, Somers Julia, Demir Emek
Abstract excerpt
BACKGROUND: Genes implicated in tumorigenesis often exhibit diverse sets of genomic variants in the tumor cohorts within which they are frequently mutated. For many genes, neither the transcriptomic effects of these variants nor their relationship to one another in cancer processes have been well-characterized. We sought to identify the downstream expression effects of these mutations and to determine whether...
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