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Article

A tipping point in neuropsychiatric genetics.

Neuron - 5 May 2021

McClellan Jon M, King Mary-Claire

Abstract excerpt

Severe neuropsychiatric disorders are so genetically heterogeneous that virtually every unrelated patient harbors different clinically significant alleles. By studying schizophrenia in the Ashkenazi Jewish founder population, Lencz and co-authors identified rare severe alleles each shared by a few patients. Experimental evaluation of an implicated protocadherin allele revealed failure to form homophilic cellular...

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Identifiers

PMID: 33957066
DOI: 10.1016/j.neuron.2021.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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