Article
An evolutionary perspective on complex neuropsychiatric disease.
Neuron - 3 Jan 2024
McClellan Jon M, Zoghbi Anthony W, Buxbaum Joseph D, Cappi Carolina, Crowley James J, Flint Jonathan, Grice Dorothy E, Gulsuner Suleyman, Iyegbe Conrad, Jain Sanjeev, Kuo Po-Hsiu, Lattig Maria Claudia, Passos-Bueno Maria Rita, Purushottam Meera, Stein Dan J, Sunshine Anna B, Susser Ezra S, Walsh Christopher A, Wootton Olivia, King Mary-Claire
Abstract excerpt
The forces of evolution-mutation, selection, migration, and genetic drift-shape the genetic architecture of human traits, including the genetic architecture of complex neuropsychiatric illnesses. Studying these illnesses in populations that are diverse in genetic ancestry, historical demography, and cultural history can reveal how evolutionary forces have guided adaptation over time and place. A fundamental truth...
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