Article
A joint history of the nature of genetic variation and the nature of schizophrenia.
Molecular psychiatry - 1 Feb 2015
Kendler K S
Abstract excerpt
This essay traces the history of concepts of genetic variation and schizophrenia from Darwin and Mendel to the present. For Darwin, the important form of genetic variation for evolution is continuous in nature and small in effect. Biometricians led by Pearson agreed and developed statistical genetic approaches utilizing trait correlations in relatives. Mendel studied discontinuous traits and subsequent...
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