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Article

Oocyte-derived microvilli control female fertility by optimizing ovarian follicle selection in mice

5 May 2021

Abstract excerpt

Crosstalk between oocytes and surrounding somatic cells is crucial for mammalian oogenesis, but the structural mechanisms on oocytes to control female reproduction remain unknown. Here we combine endogenous-fluorescent tracing mouse models with a high-resolution live-cell imaging system to characterize oocyte-derived mushroom-like microvilli (Oo-Mvi), which mediate germ-somatic communication in mice. We perform...

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PMID: 33953177
DOI: 10.1038/s41467-021-22829-2

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