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A SARS-CoV-2 Variant with L452R and E484Q Neutralization Resistance Mutations

6 May 2021

Abstract excerpt

The emergence of SARS-CoV-2 variants that reduce antibody neutralization and vaccine efficacy is of significant global concern. On 24 March 2021, the Indian SARS-CoV-2 Consortium on Genomics reported that a variant containing a unique combination of two spike receptor-binding domain (RBD) neutralization resistance mutations, L452R and E484Q, made up 15 to 20% of positive cases in the Maharashtra state, which...

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PMID: 33952596
DOI: 10.1128/jcm.00741-21

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