Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High frequency of PIK3CA and TERT promoter mutations in fibromatosis-like spindle cell carcinomas.

Journal of clinical pathology - 1 Jul 2022

Zhong Siyuan, Zhou Shuling, Li Anqi, Lv Hong, Li Ming, Tang Shaoxian, Xu Xiaoli, Shui Ruohong, Yang Wentao

Abstract excerpt

AIMS: Fibromatosis-like spindle cell carcinomas (FLSCCs) are rare metaplastic breast cancers (MBCs) that are characterised by bland spindle cells in a collagenous stroma. Although some MBCs are highly malignant, FLSCCs have indolent behaviour with low potential for lymph node or distant metastasis. Owing to their rarity, there are limited genomic data on FLSCCs. In this study, we analysed the clinicopathological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Carcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Fibroma

Share to Mutation

Share to Promoter Regions, Genetic

Share to Telomerase

Source

Identifiers

PMID: 33952589
DOI: 10.1136/jclinpath-2020-207071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High frequency of PIK3CA and TERT promoter mutations in fibromatosis-like spindle cell carcinomas.PMID 33952589Read ↗

TERT Promoter Mutation c.-124C>T Commonly Occurs in Low-Grade Fibromatosis-like Metaplastic Breast Carcinoma.Semantic proximity Read ↗

Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing.Semantic proximity Read ↗

MED12, TERT and RARA in fibroepithelial tumours of the breast.Semantic proximity Read ↗

TERT promoter hotspot mutations and gene amplification in metaplastic breast cancerSemantic proximity Read ↗

Morphologic and genetic heterogeneity in breast fibroepithelial lesions-a comprehensive mapping study.Semantic proximity Read ↗

Genetic and Clinical Characteristics of Phyllodes Tumors of the BreastSemantic proximity Read ↗

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression.Semantic proximity Read ↗

[Pathological features and clinicopathological significance of TERT promoter mutation in breast fibroepithelial tumors without definite diagnosis].Semantic proximity Read ↗

Phyllodes Tumors: Diagnostic, Investigative and Therapeutic Challenges with Special Focus on Malignant Phyllodes TumorsSemantic proximity Read ↗

A novel genomic panel as an adjunctive diagnostic tool for the characterization and profiling of breast Fibroepithelial lesions.Semantic proximity Read ↗

Periductal Stromal Tumor of the Breast with a TERT Promoter Mutation: First Case Report with Comprehensive Molecular Analysis.Semantic proximity Read ↗

Low-grade fibromatosis-like spindle cell carcinomas of the breast are molecularly exiguous.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.