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Article

How adding a single methylene to dihydrofolate reductase can change its conformational dynamics.

The Journal of chemical physics - 28 Apr 2021

Penhallurick Ryan W, Harold Alliyah, Durnal Maya D, Ichiye Toshiko

Abstract excerpt

Studies of the effects of pressure on proteins from piezophilic (pressure-loving) microbes compared with homologous proteins from mesophilic microbes have been relatively rare. Interestingly, such studies of dihydrofolate reductase show that a single-site mutation from an aspartic acid to a glutamic acid can reverse the pressure-dependent monotonic decrease in activity to that in a monotonic pressure-dependent...

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Identifiers

PMID: 33940851
DOI: 10.1063/5.0047942
PMCID: PMC8068499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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