In silico evidence that substitution of glycine for valine (p.G8V) in a common variant of TMPRSS2 isoform 1 increases accessibility to an endocytic signal: Implication for SARS-cov-2 entry into host cells and susceptibility to COVID-19.

doi:10.1016/j.biochi.2024.05.004

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In silico evidence that substitution of glycine for valine (p.G8V) in a common variant of TMPRSS2 isoform 1 increases accessibility to an endocytic signal: Implication for SARS-cov-2 entry into host cells and susceptibility to COVID-19.

Biochimie - 1 Oct 2024

Calcagnile Matteo, Damiano Fabrizio, Lobreglio Giambattista, Siculella Luisa, Bozzetti Maria Pia, Forgez Patricia, Malgoyre Alexandra, Libert Nicolas, Bucci Cecilia, Alifano Marco, Alifano Pietro

Abstract excerpt

The TMPRSS2 protease plays a key role in the entry of the SARS-CoV-2 into cells. The TMPRSS2 gene is highly polymorphic in humans, and some polymorphisms may affect the susceptibility to COVID-19 or disease severity. rs75603675 (c.23G > T) is a missense variant that causes the replacement of glycine with valine at position 8 (p.G8V) in the TMPRSS2 isoform 1. According to GnomAD v4.0.0 database, the allele...

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PMID: 38754620
DOI: 10.1016/j.biochi.2024.05.004

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