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Article

Role of Cdkn2a in the Emery-Dreifuss Muscular Dystrophy Cardiac Phenotype.

Biomolecules - 6 Apr 2021

Pegoli Gloria, Milan Marika, Manti Pierluigi Giuseppe, Bianchi Andrea, Lucini Federica, Santarelli Philina, Bearzi Claudia, Rizzi Roberto, Lanzuolo Chiara

Abstract excerpt

The Cdkn2a locus is one of the most studied tumor suppressor loci in the context of several cancer types. However, in the last years, its expression has also been linked to terminal differentiation and the activation of the senescence program in different cellular subtypes. Knock-out (KO) of the entire locus enhances the capability of stem cells to proliferate in some tissues and respond to severe physiological...

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Share to Cyclin-Dependent Kinase Inhibitor p16
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33917623
DOI: 10.3390/biom11040538
PMCID: PMC8103514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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