Article
Systematic Complex Haploinsufficiency-Based Genetic Analysis of Candida albicans Transcription Factors: Tools and Applications to Virulence-Associated Phenotypes.
G3 (Bethesda, Md.) - 28 Mar 2018
Glazier Virginia E, Murante Thomas, Koselny Kristy, Murante Daniel, Esqueda Marisol, Wall Gina A, Wellington Melanie, Hung Chiung-Yu, Kumar Anuj, Krysan Damian J
Abstract excerpt
Genetic interaction analysis is a powerful approach to the study of complex biological processes that are dependent on multiple genes. Because of the largely diploid nature of the human fungal pathogen Candida albicans, genetic interaction analysis has been limited to a small number of large-scale screens and a handful for gene-by-gene studies. Complex haploinsufficiency, which occurs when a strain containing two...
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