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Chronic inflammation promotes cancer progression as a second hit

12 Sept 2023

Abstract excerpt

Acute myeloid leukemia (AML) is a malignant neoplasia of the hematopoietic system characterized by the accumulation of immature and nonfunctional leukemic blasts in the bone marrow and peripheral tissues. Mechanistically, the development of AML is explained by the "two-hit" theory, which is based on the accumulation of driver mutations that will cooperate to induce transformation. However, a significant...

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PMID: 37709251
DOI: 10.1016/j.exphem.2023.09.002

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