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Article

Control of pre-replicative complex during the division cycle in Chlamydomonas reinhardtii.

PLoS genetics - 1 Apr 2021

Ikui Amy E, Ueki Noriko, Pecani Kresti, Cross Frederick R

Abstract excerpt

DNA replication is fundamental to all living organisms. In yeast and animals, it is triggered by an assembly of pre-replicative complex including ORC, CDC6 and MCMs. Cyclin Dependent Kinase (CDK) regulates both assembly and firing of the pre-replicative complex. We tested temperature-sensitive mutants blocking Chlamydomonas DNA replication. The mutants were partially or completely defective in DNA replication and...

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Identifiers

PMID: 33909603
DOI: 10.1371/journal.pgen.1009471
PMCID: PMC8081180

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