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Article

A suppressor screen in chlamydomonas identifies novel components of the retinoblastoma tumor suppressor pathway.

Genetics - 1 Mar 2008

Fang Su-Chiung, Umen James G

Abstract excerpt

The retinoblastoma (RB) protein is a eukaryotic tumor suppressor and negative cell-cycle regulator. Chlamydomonas reinhardtii cells that lack the RB homolog MAT3 show loss of size checkpoint control and deregulated cell-cycle progression leading to the production of tiny cells. We carried out an insertional mutagenesis screen to isolate bypass suppressors of mat3 (smt mutants) that reverted the mat3 cell-size...

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Identifiers

PMID: 18385113
DOI: 10.1534/genetics.107.085977
PMCID: PMC2278067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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